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1-Testosterone: The Single Biggest Discovery To Hit The Supplement Market! 1-Testosterone is what is known as a “double bond isomer” of testosterone. It is also known as 17- hydroxyandrost-1-ene-3-one or Androst-1-ene or A1E. Although chemically the only difference between testosterone and 1-Testosterone is the position of the double bond, pharmacologically the two products are quite different. According to research done by the pharmaceutical giant G.D. Searle and published in the 1960s, 1-testosterone is over 7 times as myotrophic (anabolic) as testosterone. That makes 1-testosterone a phenomenally potent compound, surpassing even most synthetic anabolic steroids. No Aromatization 1-Testosterone differs from testosterone in another way as well. Being a 5alpha-reduced androgen (a DHT derivative) it simply cannot aromatize to estrogens. It means that your chances of getting gynecomastia (bitch tits) from 1-testosterone is essentially zero, and that water retention side effects are vastly reduced compared to other pro-hormones/pro-steroids. During the 60’s and 70’s some papers were published describing the phenomenon of oral activity seen with 1-dehydroandrostanes, including 1-testosterone and 1-AD. What was discovered was that these compounds resist metabolic deactivation by profoundly shifting what is known as the “17-keto redox potential” towards the formation of active 17beta-hydroxyl steroids. This means that when you take it, the liver serves primarily to activate the compound, rather than break it down and excrete it as it does with other prohormones and testosterone. It means that 1-testosterone is “orally active,” yet it does not impart the liver toxicity that 17alpha-alkylation does. 1-Testosterone Products
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